Madeline Whittier has a severe disease called SCID (severe combined immunodeficiency) meaning that she‘s extremely vulnerable outside and can get ill from even taking a breath of fresh air. She has to stay inside the filtered confines of her house at all times, but she‘s fine with that. She‘s never had many reasons to want to go outside. Then one day, she meets a boy named Olly, who moves into the house next to hers.

Sam is a high school student who struggles to hide her OCD from judgemental but popular and fun friends. She struggles to keep intruding thoughts at bay while trying to seem normal like every other student. Then one day, she meets Caroline, a witty girl with a great sense of humour, who introduces Sam to Poet‘s Corner. It‘s a secret room that a group of misfits meet at.