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I suspect this book was intended to be about friendship with a look into addiction as a mere subplot. Perhaps more broadly, it told the story of intense people who pour their whole selves into what they do, be it their sport, their profession, or their relationships. I read it, however, as a book about loneliness. The author, Abraham Verghese, wrote himself into this book. Surprisingly, to me, he was the most lonely character of all.